Preparing germ matter for medicinal use



(No Model.)

- .J. R. WITZEL. M

PREPARING GERM MATTER FOR MEDICINAL USE-- Patented Jan. 1, 1895.

M. Z a

UNITED STATES PATENT FFIGE.

JosnPn n. .WI'rzEL, OF PHILADELPHIA, PENNSYLVANIA,

PREPARING (iiERM MATTER FOR MEDICINAL USE.

srscuuon'rron forming sea of Letters Patent no. senses, dated-January 1,1895.

Appliostion filed November 27,1891. Serial No. 413.221. (No model.)

To all whom it may concern:

Be it known that I, JOSEPH R. WITZEL, a citizen of the United States,residing in the city and county of Philadelphia, State of Pennsylvania,have invented a new and useful Improvement in Methods of Preparing GermMatter for Medicinal Use, which immentary constituents of the said germor germ material, and rendering it better lit for therapeutic purposes,and for this purpose it consists of the method hereinafter set forth,whereby the germ matter as taken from the corpse, saidmatter being ineither a solid or a liquid condition, or partly solidand partly liquid,is placed in'z'acuo and subjected to a series of succussions anddilutions for the purpose described.

In the figure inthe drawing, which represents a side view of a device orapparatus suitable for carrying out my process, A designates a box orother vessel suitably supported in or on one end of the lever B,the-other end of said lever being pivoted to a standardror frame 0.

, Projecting from one side ot the lever'B is a pin D, which fits in acam grooveE in the side of the wheel F secured to the .shhft G. The saidshaft is mounted in the frame 0, and is provided with a handle II forrotating it.

' The vessel A is adapted to inclose a vial or other suitable vessel J,containing t e germ matter in vacuo, and is provided with soap K, which,when screwed on the body of the vessel A,bears against the cork'L of thevial J, so as to keep the same'ln place. The vial J is provided with avalve M for opening or- .closing the mouth-thereof.

Incan'ying out. my process of preparing the germ matter for medicinaluse, the said matter is placed in the vial J, which may be of any shape,so as to occupy about one-third of the space within the same. withdrawnfrom the vial by means of an air; exhaust pump,

of the vial closed. The vial J is now placed.

The air is now and the valve M in the mouth in the box A, and the cap Kscrewed thereon,

so as to bear against the cork L, which had been inserted in the mouthof the vial J, and thereby hold the latter in position within the box A,while the shaft G is rotated by means of the handle H, so as to rotatethe wheel F, and thereby raise and lower the lever 13, thus imparting a.series of succussions to the germ matter held in oacub in the vial J.After the era: matter has been suh ected to the sucb cussions for aboutfive minutes heat is applied to the same, and the germ matter kept atboiling point until all vitality therein is destroyed. cool room. If,after cooling, it is discovered by microscopic examination or otherwise,that the germs still have vitality, the material is again placed in'vacuo, and a quantity of nitrogen gas is introduced in any suitablemanner, so as to fill the germ material. After It is then set aside in adark and being kept inlthis condition for about nine hours and beingsubjected to a number of successions so as to bring the germ Q'nass incontact with the nitrogen, the latter is removed from the germs whichdccup'y about one-third of the vial, and the air withdrawn from thesame, and the germs again subjected to a series of successions. Air isnow allowed to enter the vial and the germ material is diluted withdistilled water, alcohol or any other suitable fluid, to anydesired-proportion, preferably one part of germ matter to nine parts oialcohol, when it is poured into asuitable vessel or jar provided with avalve for attachment of an air pump thereto. The said vessel being aboutone-third full of germ matter, 1 has the air withdrawn from it, and thematerial therein issubjected to a number of succussions. Air is nowallowed to enter the vessel and fill the vacuum. The germ material.

is again diluted with alcohol or any other suitable fluids, andistreated inlike'manner, asz vat the preceding dilution. ,By thnssuccussion in 'vacuo depriving the germ material of air and separatingthe molecules so as to aid capillary absorption by the blood vessels.'lhe germ or germ material prepared as described, may be used internallyor exterrlally, by vaccination, injection, or as a spray.

By having the germ matter placed in vacuo before succussion, the aircells'are dilated,

and are more easily broken or severed. The air and its impurities areremoved, thus affording the best condition for succussing or agitatingas the liquid strikes the vessel with out a cushion. Particles held insolution or suspension are more finely divided and subdivided, andtherebyincrease and aid capillary absorpti nby the blood vessels. Itmakes a more unifo m mixture and improves the keeping qualities ofarticles in vacuo. In many cases it requires less material or medicineto producethe desired therapeutic efiects, as the absorption is morereadily accomplished by the capillary vessels when cells or particlesare finely divided and sub-divided. Having thus described my invention,what I claim as new, and desire to secure by Letters Patent, is--" I 1.The process of preparing medicinal substances, consisting'in firstplacing the said substance in vacuo, and then subjecting it when in thesame to a number of succu-ssions, substantially as described.

2. The process of preparing germ matter for medicinal use, consisting infirst placing the same in vacuo, and while therein subjecting the sameto succussions, then removing and diluting it, and again subjecting itin vacuo to succussion, substantially as described.

3. Theprocess of preparing germ matter for medicinal use, consisting infirst placing the same in vacuo, and while therein subjecting it tosuccussions, then admitting air and diluting the said matter, heatingitand subjecting it to further succussions, substantially as described.

4. The process of preparing'germ matter for medicinal use, consisting infirst placing the same in vacuo, then subjecting it to a se-' ries ofsuccussions, then repeatedly diluting it in air and subjecting ittosuccussions in vacuo, next introducing a vitality-destroying gas orsubstance into the mass so treated, and then subjecting it tosuccessions as before, substantially as described.

. JOSEPH R. 'WI'lZEl. l itnesses:

JOHN A. WIEDERSi-IEIM, A. P. JENNINGS.

